abstract：:Two variant sublines of the murine 3LL carcinoma with divergent potentials for lymphatic metastasis were used to assess the relationship between tumor cell potential for lymphatic metastasis and its ability to adhere specifically to lymphatic tissue. Using fresh cryostat sections of lymph nodes and spleens, it was fou...

journal_title：Clinical & experimental metastasis

authors： Brodt P

更新日期：1989-05-01 00:00:00

abstract：:Previous studies have shown that thrombospondin (TSP) is an adhesion factor for some human tumor cells. The previous studies have shown further that tumor cells which utilize TSP as an adhesion factor also synthesize it. This study continues the effort to understand how TSP production and expression are regulated in h...

journal_title：Clinical & experimental metastasis

authors： Varani J,Riser BL,Hughes LA,Carey TE,Fligiel SE,Dixit VM

更新日期：1989-05-01 00:00:00

abstract：:Proliferation capacity and MHC class I antigen expression of two Lewis lung carcinoma (3LL) metastatic variants (C87, BC215) grown under defined experimental conditions (serum-free defined medium or 10 per cent serum) have been studied following exposure to MoAb 135-13C which recognizes on these cells a tumor surface ...

journal_title：Clinical & experimental metastasis

authors： Sacchi A,Piaggio G,Rizzo MA,Falcioni R,Kennel SJ

更新日期：1989-01-01 00:00:00

abstract：:Aromatic polyamidines containing two, three or four benzamidine residues inhibit proteinase activity and proliferation of different human tumor cell lines, including leukemic (K562, HEL), melanoma (Colo 38) and B-lymphoid (WI-L2) cell lines. In addition, the benzamidine derivatives analysed in the present study inhibi...

journal_title：Clinical & experimental metastasis

authors： Nastruzzi C,Feriotto G,Spandidos D,Ferroni R,Guarneri M,Barbieri R,Gambari R

更新日期：1989-01-01 00:00:00

abstract：:A murine mammary carcinoma, which had a high potential for metastasis to the lungs, was established in culture, and from the parent line several clonally derived variants were isolated, showing different characteristics including metastatic potential. C1, a high metastatic clone, and C2, a low one, were selected for f...

journal_title：Clinical & experimental metastasis

authors： Lee AE,Rogers LA,Jeffery RE,Longcroft JM

更新日期：1988-11-01 00:00:00

abstract：:Cancer cells selected from a cultured murine fibrosarcoma by rapid migration through micropore membranes moved considerably faster through such membranes and invaded biological tissues much more efficiently than did the unselected parent cells. The present data show that populations of cells selected by unstimulated m...

journal_title：Clinical & experimental metastasis

authors： Grimstad IA

更新日期：1988-07-01 00:00:00

abstract：:Repeated administration of the hepatic lectin blocking agents D-galactose or arabinogalactan completely prevented the settling of metastatic cells of sarcoma L-1 tumor in the liver of Balb/c mice and greatly reduced the colonization process of highly metastatic ESb lymphoma cells of the liver of DBA/2 mice. Therefore,...

journal_title：Clinical & experimental metastasis

authors： Beuth J,Ko HL,Schirrmacher V,Uhlenbruck G,Pulverer G

更新日期：1988-03-01 00:00:00

abstract：:We have used 5'-deoxy-5'-S isobutyl-thioadenosine (SIBA), an analog of S-adenosylhomocysteine, alone or in association with a methionine-depleted diet in order to obtain an antitumoral effect in two different tumor models: a transplantable rat rhabdomyosarcoma (RMS-J1) induced by i.m. injection of nickel and the well-...

journal_title：Clinical & experimental metastasis

authors： Breillout F,Poupon MF,Blanchard P,Lascaux V,Echinard-Garin P,Robert-Gero M

更新日期：1988-01-01 00:00:00

abstract：:In order to study the usefulness of treatment with vinblastine (VLB) in the prevention of cancer metastasis in squamous cell lung cancer, 50 patients with locoregional disease were randomized to receive either locoregional RT alone (group A) or a weekly intravenous bolus injection of VLB (6 mg/m2) concurrently with an...

journal_title：Clinical & experimental metastasis

authors： Schallier DC,De Neve WJ,De Greve JL,Van Belle SP,De Wasch GJ,Dotremont G,Storme GA

更新日期：1988-01-01 00:00:00

abstract：:Two widely used B16 melanoma cell lines of low and high lung colonizing potential (B16-F1 and B16-F10) were compared in their ability to induce platelet aggregation. The results of these experiments showed a reproducible difference in platelet aggregating activity of these two cell lines which directly correlated with...

journal_title：Clinical & experimental metastasis

authors： Kimura AK,Mehta P,Xiang JH,Lawson D,Dugger D,Kao KJ,Lee-Ambrose L

更新日期：1987-04-01 00:00:00

abstract：:Recent studies have indicated that KHT fibrosarcoma or B16 melanoma cell variants capable of forming experimental metastases in the lungs of mice after i.v. injection are created stochastically at high rates (approximately 10(-5)/cell/generation). Expression of this phenotype is unstable and hence expanding population...

journal_title：Clinical & experimental metastasis

authors： Young SD,Hill RP

更新日期：1986-07-01 00:00:00

abstract：:The effects of treatment of human lung carcinoma cell line A 549 with recombinant DNA-derived human leukocyte interferons A (rIFN-alpha A) or D (rIFN-alpha D), and human lymphoblastoid interferon (Wellferon) on in vitro cell invasion were investigated in a quantitative invasion assay using human amnion. The A 549 cell...

journal_title：Clinical & experimental metastasis

authors： Ravine TJ,Ledinko N

更新日期：1986-07-01 00:00:00

abstract：:Intravenous infusions of perfluorochemical emulsions, combined with administration of inspired oxygen or carbogen have been found to improve tumor oxygenation and increase the response of solid tumors in animals to radiotherapy. Fluosol-DA 20 per cent, the only perfluorochemical emulsion currently approved for testing...

journal_title：Clinical & experimental metastasis

authors： Rockwell S,Irvin CG,Nierenburg M

更新日期：1986-01-01 00:00:00

abstract：:The effect of thioglycollate-elicited macrophages (TG-M phi) on natural killer (NK)-cell activity and metastases formation in mice was investigated. Intravenously (i.v.) inoculated TG-M phi inhibited spleen NK activity of normal mice and abrogated polyinosinic: polycytidylic (poly I:C) induced augmentation of NK cell ...

journal_title：Clinical & experimental metastasis

authors： Gorelik E,Wiltrout RH,Brunda MJ,Bere WE,Herberman RB

更新日期：1985-04-01 00:00:00

abstract：:ECA109 human oesophageal carcinoma cells were injected either subcutaneously or intraperitoneally into BALB/CATc 1-nu/nu mice. After 23 weeks tumours were examined histologically and by scanning electron microscopy. Subcutaneous ECA109 tumours were well-delineated without signs of invasion. By contrast, intra-abdomina...

journal_title：Clinical & experimental metastasis

authors： Gao J,Xue KX,Li BG,Dong HY,Wei LS,Zhang ZH,Tian S,Xu ZG

更新日期：1984-07-01 00:00:00

abstract：:Metastatic variant sublines of the murine RAW117 large cell lymphoma or lymphosarcoma have been established in vitro by sequential cycles of harvesting of liver tumor nodules after intravenous inoculation of tumor cell suspensions into syngeneic BALB/c mice. After five and ten in vivo selections for liver colonization...

journal_title：Clinical & experimental metastasis

authors： McGuire EJ,Mascali JJ,Grady SR,Nicolson GL

更新日期：1984-07-01 00:00:00

abstract：:The concurrent administration of Metrazol (60 mg/kg, i.v.) to anaesthetized rats enhances the cerebral penetration of the anticancer agent razoxane. Such an enhancement leads to an increase in the therapeutic efficacy of razoxane against intracerebrally sequestered L1210 leukaemia cells in mice. The combination of Met...

journal_title：Clinical & experimental metastasis

authors： Greig N,Newell D,Hellmann K

更新日期：1984-01-01 00:00:00

abstract：:The lungs of BR6 breeding female mice which had developed spontaneous mammary tumours, were examined histologically for the presence of metastases. Metastatic nodules, or tumour cell emboli within blood vessels, were found in the lungs of 3 out of 42 (7 per cent) mice with pregnancy-dependent tumours, and in 33 out of...

journal_title：Clinical & experimental metastasis

authors： Lee AE,Pang LS,Rogers LA,Jeffery RE

更新日期：1983-07-01 00:00:00